Year : 2022

Volume : Volume 13

Issue : Issue 4

Address for correspondence :
Dr. Kush Pathak
dr.kushpathak18@mmumullana.org

Abstract

Background: Oral squamous cell carcinoma (OSCC) cancer is the sixth most common cancer worldwide with approximately 400,000 new cases reported annually. A number of bacterial species are associated with different cancers. The present study aims to analyze the prevalence and prognostic significance of Helicobacter pylori in OSCC. Materials and Methods: Formalin-fixed paraffin-embedded blocks of previously diagnosed cases of OSCC and normal oral epithelium were retrieved. Corresponding tissue sections were subjected to hematoxylin and eosin staining and immunohistochemical staining. Results: The immunohistochemical expression of H. pylori scores was higher in oral carcinoma cases than that of normal mucosa which was statistically highly significant (P = 0.00). A significant association was observed between immunohistochemical expressions of H. pylori scoring and histopathological grades of OSCC (P = 0.033) and an inverse correlation was found. Conclusion: This study has shown that clinically, H. pylori scores were found to be highly expressed in higher stages of OSCC whereas histopathologically, lower grades of OSCC showed higher H. pylori scores. H. pylori expression is independent of survival rate in these cases in 3-year duration.

Keywords: Helicobacter pylori, Immunohistochemical expression, Oral squamous cell carcinoma, Prognosis and survival.