Year : 2015

Volume : Volume 5

Issue : Issue 1

Address for correspondence :
Dr. Jazib Nazeer.
jazibNazeer@gmail.com

Abstract

Background:  Leukoplakia has been studied for many years and is commonly agreed upon as representing the most common pre-malignant oral mucosal lesion. Oral leukoplakia (OL) is the most common potentially malignant disorder of the oral cavity, which can precede oral squamous cell carcinoma. Ki-67 is a nuclear antigen which is present in the peri-chromosomal region during mitosis and seems to be a non-histone protein, the objective of this research was to detect the expression of Ki-67 in leukoplakia cases with dysplasia and without dysplasia and co relate its expression in relation to normal mucosa. Materials and Method: Two sections were made from each paraffin block of respective group. The H&E staining was done for one of section. The second section was used for IHC demonstration of Ki-67expression. Results: In this study Ki-67 positive nuclei were found only at basal and parabasal layer, In the present study 87.5% of the leukoplakia shows positivity for Ki-67 staining, no significant difference were observed in expression of Ki-67 between non dysplastic and dysplastic group (p=.0589) Conclusion: it can also be documented that Ki-67 may also be considered as a tumor marker. Expression of Ki67 protein may help in determining the prognosis as well as play a key role in early detection of squamous cell carcinoma, which may help not only in determining the prognosis but also plays a role in gene therapy in future.

Keywords: Leukoplakia, ki-67, Epithelial dysplasia.