Journal of Research and Advancement in Dentistry
Official publication of Magadh University and Kolhan University, Government of Bihar and Jharkhand, India
Official publication of Magadh University and Kolhan University, Government of Bihar and Jharkhand, India
Year : 2020
Volume : Volume 11
Issue : Issue 2s
Address for correspondence :
Dr. Ritika Agarwal.
drritikaagarwal@gmail.com
Background: Oral leukoplakia is a premalignant lesion caused by smoking or smokeless tobacco. The present study was conducted to assess role of oral lycopene in patients with oral leukoplakia. Materials & Methods: 40 clinically/histopathologically proven cases of oral leukoplakia, and healthy subjects without any oral deleterious habits were also enrolled. Determination of lycopene in blood plasma by high performance using liquid chromatography. Results: Out of 60 subjects, males were 40 and females were 20. Group I had non- smokers, group II had smokers without leukoplakia and group III had smokers with leukoplakia. Each group had 20 subjects. The mean lycopene level in group I was 132.8 ng/ml, group II had 40.2 ng/ml and group III had 29.6 ng/ml. The difference was significant (P< 0.05). Conclusion: The level of lycopene was highly reduced in patients with leukoplakia as compared to healthy subjects.
Keywords: Leukoplakia, Lycopene, Smoking.
