Journal of Research and Advancement in Dentistry
Official publication of Magadh University and Kolhan University, Government of Bihar and Jharkhand, India
Official publication of Magadh University and Kolhan University, Government of Bihar and Jharkhand, India
Year : 2021
Volume : Volume 12
Issue : Issue 2
Address for correspondence :
Dr. Jeemee Patel
jeemeepatel@gmail.com
Background: There is evidence that clonidine, an alpha-2 adrenoceptor agonist, used as a central antihypertensive agent, enhances local anesthesia and analgesia in a variety of routes of administration and clinical circumstances. The aim of the study was to compare the efficacy of anesthesia and hemodynamic parameters of clonidine and epinephrine in lignocaine for lower third molar surgery Material and Methods: Forty patients who reported to the Department of Oral and Maxillofacial Surgery requiring removal of impacted mandibular third molar were selected for the study. Patients were randomly divided into two groups, regardless of gender: Group 1 (Clonidine group) received 2.5 ml of 2% lignocaine with clonidine (15 µg/ml) and Group 2 (Adrenaline group) received 2.5 ml of 2% lignocaine with adrenaline (12 µg/ml). Hemodynamic parameters (heart rate, systolic blood pressure [SBP], diastolic blood pressure [DBP], and mean arterial pressure [MAP]) were recorded preoperatively, intraoperatively, and postoperatively. The onset of anesthesia and duration of anesthesia were recorded using pinprick test for both groups. Postoperatively, patients were evaluated for pain experience by the visual analog scale and verbal rating scale. Results: There was no significant difference between the groups with respect to age, gender distribution, difficulty of impaction, and duration of the procedure. There was a decrease in SBP, DBP, and MAP within the clonidine group when compared to the baseline preoperative values of clonidine group. There was no statistically significant difference in the onset and duration of anesthesia between the groups. Conclusion: Clonidine when used as an adjuvant to adrenaline in lignocaine can be safe and useful alternative to adrenaline. It is as efficient as adrenaline in respect to onset, duration, and intensity of anesthesia. Hemodynamic parameters are stable and better than adrenaline.
Keywords: Adrenaline, Clonidine, Lignocaine, Systolic Blood Pressure.
