Year : 2015

Volume : Volume 5

Issue : Issue 3

Address for correspondence :
Dr. Prerna Kataria
prernakataria@gmail.com

Abstract

Background:  The local delivery of therapeutic agents to periodontal pockets has the benefit of administering more drugs at the target site, thus achieving high intrasulcular drug concentrations, avoiding its systemic side effects, and a better patient compliance. This present study was conducted to evaluate the efficacy of  locally delivered 1.2% atorvastatin Gel in comparison to 1% ornidazole gel in the treatment of chronic periodontitis. Materials and Methods: 44 Subjects selected on the basis of inclusion criteria were categorized into two treatment groups. GROUP I (n=22): Patients treated by SRP with subgingival 1.2% Atorvastatin gel. GROUP II (n=22): Patients treated by SRP with subgingival 1% ornidazole gel. Clinical parameters of mean sulcular bleeding index, probing depth, relative attachment level were recorded at baseline, 1 month and 3 months and GCF TNFα levels were recorded at baseline and 1 month. Result: Overall observation in the present study on the basis of clinical and biochemical results achieved has revealed that in both Group A (SRP + 1.2% Atorvastatin) and Group B (SRP + 1% Ornidazole), there was statistically significant reduction in clinical parameters (m SBI, PD), gain in RAL at 1 and 3 months postoperatively, along with the GCF TNF-α levels. On comparison between Group A and Group B, both the Groups exhibited similar significant improvement in all the clinical parameters but group A exhibited more significant reduction in GCF TNF α levels as compared to group B. Conclusion: The results of the present study favour the use of both locally delivered atorvastatin and ornidazole in the treatment of chronic periodontitis.

Keywords: Chronic periodontitis, statins, ornidazole, local drug delivery, TNF alpha.