Year : 2016

Volume : Volume 6

Issue : Issue 2

Address for correspondence :
Dr. Mirank Doshi
mirank1410@gmail.com

Abstract

Background:  Endodontic healing involves a series of rapid increases in specific cell populations that prepare the site for repair, deposit new matrices and finally, mature the wound. Upon completing their tasks, these specific cell types must be eliminated from the site prior to the progression to the next phase of healing. The most logical method of cellular down-regulation is through apoptosis. Apoptosis allows for the eliminations of entire populations without tissue damage or an inflammatory response. This review discusses which cells dominate the various phases of tissue repair and how the cellular pattern may vary during different phases. The potential mechanisms involved in the down-regulation of inflammation and fibrosis are also covered. The studies that support the hypothesis that apoptosis is involved in the regulations of wound healing are discussed. The evidence supporting potential cell signals involved in the induction of apoptosis in tissue repair are examined and how dysregulation of apoptosis can lead to pathologic forms of healing such as excessive scarring and fibrosis also covered. By understanding the mechanisms controlling apoptosis and tissue repair, one may eventually develop therapeutic modalities to endodontic healing.

Keywords: Dentistry, endodontics, healing.