Year : 2020

Volume : Volume 11

Issue : Issue 3

Address for correspondence :
Dr. Mohsin Ghanchi.
mohsinghanchi@gmail.com

Abstract

Background:  Oral submucous fibrosis is the most common precancerous condition affecting the oral cavity. Early detection and knowledge of the dysplastic changes occurring in OSMF are helpful in prevention or progress of such lesions turning into oral cancer. Hence the aim was to estimate the serum superoxide dismutase (SOD) and serum Malondialdehyde (MDA) levels in patients with OSMF.  Materials and Method: A total of 120 patients were included in the present study ranging between 18 to 75 years. Sixty OSMF cases which were clinically diagnosed and histopathologically confirmed were divided into different stages and grades respectively. Sixty healthy subjects without any habits and clinically normal appearing oral mucosa were included as controls. Serum MDA will be measured using the method of Ohkawa et al. and Serum Superoxide will be measured using the method of Fridvich and Mishra.  Result: Serum MDA and serum SOD were compared within the clinical stages and histopathological groups of OSMF patients, analyzed by analysis of variance (ANOVA) test. Results showed a very high significant difference. The MDA and SOD levels were compared between the clinical stage and histopathological grades of OSMF patients, analyzed by student 't’ test.  Conclusion: The present study showed significant increase in the serum MDA levels in all the clinical stage and histopathological grades, the maximum being in stage IV and Grade III. It was also observed a significant decrease in SOD levels in all the clinical stages and histopathological grades of OSMF patients, the maximum being in stage IV and grade III.

Keywords: MOD, oral cancer, oral precancerous, SOD.