Year : 2024

Volume : Volume 15

Issue : Issue 6

Address for correspondence :
Dr. Vivek Kumar
drvivek1909@gmail.com

Abstract

Background: In oral diagnostics, there is a great challenge to determine biomarkers for screening and evaluating the disease activity. Biomarkers can also serve as a useful tool to measure the efficacy of the therapy. Hence, the aim of the present study is to determine the serum and salivary levels of alkaline phosphatase (ALP) and acid phosphatase (ACP) in patients diagnosed with chronic periodontitis before and after phase I therapy with or without adjunct to systemically administered doxycycline. Materials and Methods: 60 participants in the age range of 40 and 56 years reporting to the Outpatient Department of Periodontics who qualified for the inclusion criteria were included in this study. Clinical parameters recorded were plaque index (PI), gingival index (GI), sulcus bleeding index (SBI), probing pocket depth, and clinical attachment level. Saliva and serum samples were collected for the estimation of ALP and ACP. Results: The serum ALP levels reduced significantly when baseline values of Group A (109.20 ± 22.48) were compared to 3-month post-therapy of Group B (283.50 ± 34.68) and also 3-month post-therapy of Group C (186.75 ± 38.05). Salivary ALP levels also showed a significant difference when baseline values of Group A (132.25 ± 26.48) were compared to 3-month post-therapy of Group B (306.50 ± 47.60) and Group C (158.75 ± 30.25). A significant difference was also found with respect to serum and salivary ACP levels at 3-month post-therapy. Conclusion: Salivary diagnosis extends an easy, safe, economical, and non-invasive approach to disease detection and possesses a high perspective to reconstitute the next generation of diagnostics.