Year : 2015

Volume : Volume 5

Issue : Issue 3s

Address for correspondence :
Dr. Anusha Vaddi
anushareddy999@gmail.com

Abstract

Background:  Oral squamous cell carcinoma (OSCC) is a global health problem and a leading cause of morbidity and mortality. Consumption of Tobacco products, smoking and alcohol are the predominant risk factors, although other factors such as diet (malnutrition) may affect the risk. Toxic agents and free radicals released from these agents cause oxidative damage to cells of the oral tissue. Data from previous studies suggested, Nutritional agents (such as carotenoids, curcumin, flavonoids) with their antioxidant and anti-inflammatory properties have a significant role in modulating genetic pathways associated with carcinogenesis. Evidence from several animal and clinical studies on oral potentially malignant disorders showed an inverse relation between levels of antioxidants and risk of progression to cancer. Expanding knowledge on cancer genomics made it possible to develop strategies that target specific dysregulated molecular events associated with the pathogenesis of cancer. Prevention using natural chemopreventive agents (Nutraceuticals) has been suggested as an innovative strategy. Studies had shown treatment with nutritional agents has the potential to hamper or reverse steps involved in carcinogenesis.

Keywords: Oral cancer, chemoprevention, Nutraceuticals.