Year : 2016

Volume : Volume 6

Issue : Issue 1s

Address for correspondence :
Dr. Thanuja Seethapathy
thanujabds@gmail.com

Abstract

Background:  Pemphigus is a blistering disorder caused by autoantibodies that result in the dissolution of intercellular attachments within the epidermis and mucosal epithelium. Though rare, without treatment it may be life-threatening, and its pathobiology provides important insight into the molecular mechanisms of keratinocyte adhesion. Pemphigus vulgaris, by far the most common type (accounting for more than 80% of cases worldwide), involves the mucosa and skin. It is one such lesion where oral lesions are preceded by cutaneous lesions. Hence, dental professionals must be efficient to recognize the clinical features of pemphigus vulgaris to ensure early diagnosis and treatment, so that it determines the favorable prognosis and course of the disease. Here in this article, we report a case on oral pemphigus vulgaris.

Keywords: Pemphigus vulgaris, Autoimmune disease, Keratinocytes.